8-Hydroxyquinoline (8-HQ)
Khoom Muag: 8-Hydroxyquinoline (8-HQ) nrog cov khoom zoo
CAS Nr .: 148-24-3
Molecular Formula: C9H7NO
Cov qauv qauv:
Siv: Pharmaceutical intermediates; Tshuaj tua kab thiab dye intermediates
Specifications:
| Yam khoom | Txuj |
| Qhov tshwm sim | Yuav luag dawb los yog lub teeb xim av crystalline hmoov los yog spiculate crystals |
| tsw | Phenolic |
| Kev daws teeb meem (10% hauv alc) | Xyaum kom meej |
| Cov hlau hnyav | ≤ 20ppm |
| Residue ntawm ignition | ≤ 0.2% |
| Hlau | ≤ 20ppm |
| Melting ntau | 72-75 ℃ |
| Chloride | ≤ 0.004% |
| Sulfate | ≤0.02% |
| Assay | 99-99.8% |
| 5-Hydroxyquinoline | ≤0.2% |
Kev tawg
Soluble nyob rau hauv ethanol, acetone, chloroform, benzene thiab mineral acid, yuav luag insoluble nyob rau hauv dej.
8-hydroxyquinoline yog amphoteric, soluble nyob rau hauv muaj zog acids thiab bases, ionized rau hauv tsis zoo ions nyob rau hauv bases, khi rau hydrogen ions nyob rau hauv acids, thiab muaj qhov tsawg tshaj plaws solubility ntawm pH = 7.
Kev siv tshwj xeeb
1. Raws li cov kws tshuaj nruab nrab, nws tsis yog tsuas yog cov khoom siv raw rau kev sib txuas ntawm kexieling, chloroiodoquinoline thiab paracetamol, tab sis kuj yog qhov nruab nrab ntawm dyes thiab tshuaj tua kab. Cov khoom no yog ib qho nruab nrab ntawm halogenated quinoline anti amoeba tshuaj, nrog rau quiniodoform, chloroiodoquinoline, diioquinoline, thiab lwm yam. Cov tshuaj no ua si lub luag hauj lwm anti amoeba los ntawm inhibiting plab hnyuv kab mob. Lawv muaj txiaj ntsig zoo rau amoeba dysentery thiab tsis cuam tshuam rau lub plab hnyuv amoeba protozoa. Nws tau tshaj tawm txawv teb chaws tias cov tshuaj no tuaj yeem ua rau subacute spinal qaum optic neuropathy, yog li nws tau raug txwv hauv Nyiv thiab Tebchaws Meskas. Diioquinoline ua rau tus kab mob no tsawg dua chloroiodoquinoline. 8-hydroxyquinoline kuj yog ib qho nruab nrab ntawm dyes thiab tshuaj tua kab. Nws sulfate thiab tooj liab ntsev yog cov tshuaj tua kab mob zoo heev, tshuaj tua kab mob thiab tshuaj tiv thaiv kab mob. Cov khoom yog ib tug complexometric qhia rau tshuaj ntsuam xyuas.
2. Raws li tus neeg sawv cev complexing thiab extractant rau nag lossis daus thiab sib cais ntawm cov hlau ions, nws tuaj yeem cuam tshuam nrog Cu+ 2, ua+ 2, Mg+ 2, Ca+ 2, Sr+ 2, Ba + 2 thiab Zn+ 2,Cd+2,Al+3,Ga+3,In+3,Tl+3,Yt+3,La +3,Pb+2,B+3,Sb+ 3,Cr+3,MOO+ 22. Lub complexation ntawm Mn+ 2,Fe+ 3, CO+ 2, Ni+ 2, PIB+ 2, CE+ 3, thiab lwm yam hlau ions. Organic microanalysis, tus qauv rau kev txiav txim siab ntawm heterocyclic nitrogen, organic synthesis. Nws kuj yog ib qho nruab nrab ntawm dyes, tshuaj tua kab thiab halogenated quinolones. Nws sulfate thiab tooj liab ntsev yog zoo preservatives.
3. Ntxiv epoxy resin nplaum tuaj yeem txhim kho lub zog ntawm kev sib txuas thiab kev kub ntxhov rau cov hlau (tshwj xeeb tshaj yog stainless hlau), thiab qhov ntau npaum li cas yog 0.5 ~ 3 phr. Nws yog ib qho nruab nrab ntawm halogenated quinoline tshuaj tiv thaiv amoeba, nrog rau cov tshuaj tua kab thiab cov tshuaj tua kab. Nws tuaj yeem siv los ua cov kab mob mildew inhibitor, muaj cov tshuaj tua kab mob, stabilizer ntawm polyester cob, phenolic resin thiab hydrogen peroxide, thiab kuj yog qhov taw qhia complexometric titration rau tshuaj ntsuam xyuas.
4. Cov khoom no tsis yog tsuas yog nruab nrab ntawm cov tshuaj halogenated quinoline, tab sis kuj yog qhov nruab nrab ntawm dyes thiab tshuaj tua kab. Nws sulfate thiab tooj liab ntsev yog cov tshuaj tua kab mob zoo heev, tshuaj tua kab mob thiab tshuaj tiv thaiv kab mob. Cov ntsiab lus siab tshaj plaws (feem ntau) hauv cov tshuaj pleev ib ce yog 0.3%. Cov khoom siv tshuaj pleev thaiv hnub thiab cov khoom siv rau cov menyuam yaus hnub nyoog qis dua 3 xyoos (xws li talcum hmoov) raug txwv, thiab "tso tseg rau cov menyuam yaus hnub nyoog qis dua 3 xyoos" yuav tsum tau qhia rau ntawm daim ntawv lo. Thaum soj ntsuam cov kab mob ntawm daim tawv nqaij thiab cov kab mob eczema, qhov loj ntawm 8- hydroxyquinoline hauv emulsion yog 0.001% txog 0.02%. Nws kuj yog siv los ua tshuaj tua kab mob, tshuaj tua kab mob thiab tshuaj tua kab mob, thiab nws cov tshuaj tiv thaiv pwm muaj zog. 8- hydroxyquinoline poov tshuaj sulfate yog siv rau hauv cov tshuaj pleev ib ce thiab tshuaj pleev ib ce (feem ntau) ntawm 0.05% mus rau 0.5%.